Quantification of the lateral migration of red blood cells

Looking for the origin of the depletion layer

200 years ago, Poiseuille observed for the first time the presence of depleted layers in the vicinity of the walls of blood vessels. Through in-vitro experiments, we have characterised the migration mechanism that is at the origin of this phenomenon.

Microvasc. Res. 124, 30 (2019)

Dynamics of red blood cells

a signature of their discreet diversity

Red blood cells have a subtle mechanics which is not fully described yet by current models. We have carried out an extensive experimental study of their dynamics under shear flow, which is very sensitive to their intrinsic properties - that vary from one cell to another. This constitutes a reference work for the validation of new models.

J. Fluid Mech. 864, 408 (2019)

Phase separation of blood at bifurcations

Inversion of the usual separation law at low hematocrits

At the level of a bifurcation where the flows split unequally, red blood cells flow in such a way that the cell concentration often increases in the high flow rate branch. This splitting strongly depends on the upstream organization of the cell suspension. In some cases (high confinement and low concentration), a reverse effect is observed.

Microvasc. Research 105, 40 (2016)

Protein-induced clustering of red blood cells in microcapillaries

Plasma proteins cause red blood cells to form clusters called rouleaux which are usually assumed to be disaggregated in the circulation due to shear forces. However, despite the large shear rates present in microcapillaries, the presence of either fibrinogen or the synthetic polymer dextran leads to an enhanced formation of robust clusters.

Sci. Rep. 4, 4348 (2014)

These clusters are initiated by hydrodynamic interactions, which also contribute to their stabilization, in parallel to the adhesion-induced stabilization.

Soft Matter 12, 8235 (2016)